蛋白質の折り畳みにおける疎水性相互作用と水素結合のバランスについての最近の
研究についてお話いただく予定です。ぜひご参加ください。


講演者  : James Franck Distinguished Service Professor Emeritus, R. Stephen Berry 
           (シカゴ大学化学科)

日時    : 2005年11月15日（火）11:00-12:30
場所    : 神戸大学百年記念館「神大会館」A会議室
           交通手段（http://www.ofc.kobe-u.ac.jp/reservation/kaikan/map.htm）

タイトル: Sticky spots on proteins and how we might use them
         「タンパク質における淀み領域と我々は如何にそれを使うか？」

内容    : This deals with how exposed hydrogen bonds form attractive sites for
         protein-protein and protein-inhibitor attachments, and will include new
         work on how this gives us a new way to develop specific inhibitors for
         selected proteins. The "sticky spots" are specifically exposed hydrogen bonds
         which, when "wrapped" by hydrophobic groups, lower the system's energy and
         increase its entropy by releasing the high-dielectric water molecules from
         the vicinity of the hydrogen bond. Experiments verified this first when
         it was shown that proteins with more than a very few exposed hydrogen bonds
         attach to lipid layers, while others do not. The most recent results indicate
         that one can design inhibitors with high specificity for a given protein by
         using the nonconserved character of the exposed hydrogen bonds, even within a
         family of proteins.